IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9902688 B1

PDFFull Text
Date of Patent:
Feb. 27, 2018

Filed:

May. 10, 2016

Benzamides and nicotinamides as syk modulators

Applicant:

Portola Pharmaceuticals, Inc., South San Francisco, CA (US);

Inventors:

Zhaozhong J. Jia, San Mateo, CA (US);

Yonghong Song, Foster City, CA (US);

Qing Xu, Foster City, CA (US);

Brian Kane, Oakland, CA (US);

Shawn M. Bauer, Pacifica, CA (US);

Anjali Pandey, Fremont, CA (US);

Assignee:

PORTOLA PHARMACEUTICALS, INC., South San Francisco, CA (US);

Attorney:

Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.

Primary Examiner:

D M Seaman

Int. Cl.
CPC ...
C07D 209/08 (2006.01); C07C 237/42 (2006.01); C07D 213/82 (2006.01); C07D 231/12 (2006.01); C07D 231/38 (2006.01); C07D 233/56 (2006.01); C07D 239/48 (2006.01); C07D 249/06 (2006.01); C07D 249/08 (2006.01); C07D 257/04 (2006.01); C07D 261/14 (2006.01); C07D 275/03 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 495/04 (2006.01); C07C 237/30 (2006.01); C07D 209/40 (2006.01); C07D 213/74 (2006.01); C07D 277/42 (2006.01);
U.S. Cl.
CPC ...
C07C 237/42 (2013.01); C07C 237/30 (2013.01); C07D 209/08 (2013.01); C07D 209/40 (2013.01); C07D 213/74 (2013.01); C07D 213/82 (2013.01); C07D 231/12 (2013.01); C07D 231/38 (2013.01); C07D 233/56 (2013.01); C07D 239/48 (2013.01); C07D 249/06 (2013.01); C07D 249/08 (2013.01); C07D 257/04 (2013.01); C07D 261/14 (2013.01); C07D 275/03 (2013.01); C07D 277/42 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 495/04 (2013.01); C07C 2601/14 (2017.05);
Abstract

The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.

Find Patent Forward Citations

Loading…