The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 27, 2018

Filed:

Feb. 14, 2017
Applicant:

Jiangsu Province Institute of Traditional Chinese Medicine, Nanjing, CN;

Inventors:

Peng Cao, Nanjing, CN;

Jianxin Pu, Nanjing, CN;

Xiaoyan Sun, Nanjing, CN;

Handong Sun, Nanjing, CN;

Weiguang Wang, Nanjing, CN;

Jiao Chen, Nanjing, CN;

Xueting Cai, Nanjing, CN;

Xue Du, Nanjing, CN;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/222 (2006.01); C07C 69/12 (2006.01); C07C 69/21 (2006.01); A61K 36/00 (2006.01);
U.S. Cl.
CPC ...
C07C 69/21 (2013.01); A61K 36/00 (2013.01); C07C 69/12 (2013.01); C07C 2103/86 (2013.01); C07C 2603/86 (2017.05);
Abstract

A compound of Formula I or pharmaceutically acceptable salt thereof and its preparation method and applications, the new structure of the compound of formula I has not been reported in literature. It is isolated fromvar.and can be a compound served as Trx1 selective inhibitor. The present invention further discloses a pharmaceutical composition, preparation of the compound of Formula I and its applications in preparing medicines for preventing or treating cancer. Iso A of the present invention has the advantages of low toxicity, high safety and strong pharmacological effect, which suggests a potential prospect in pharmaceutical applications.


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