The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2018
Filed:
May. 03, 2016
International Business Machines Corporation, Armonk, NY (US);
Agency for Science, Technology and Research, Singapore, SG;
Willy Chin, Singapore, SG;
Yukti Choudhury, Singapore, SG;
Shujun Gao, Singapore, SG;
James L. Hedrick, Pleasanton, CA (US);
Xiyu Ke, Baltimore, MD (US);
Min-Han Tan, Singapore, SG;
Jye Yng Teo, Singapore, SG;
Yi Yan Yang, Singapore, SG;
International Business Machines Corporation, Armonk, NY (US);
Agency For Science, Technology and Research, Singapore, SG;
Abstract
Amphiphilic block copolymers (BCPs) were prepared comprising a poly(ethylene oxide) block and a biodegradable polycarbonate block functionalized with disulfide groups and carboxylic acid groups. The BCPs form self-assembled micellar particles in aqueous solution that can be loaded with hydrophobic drugs for therapeutic drug delivery. The loaded particles have small particle sizes (<100 nm), narrow particle size distributions, and high drug loading capacity (up to about 50 wt %) based on total dry weight of the loaded particles. Particles loaded with DOX released the DOX in response to changes in pH and glutathione (GSH) redox chemistry. The loaded particles efficiently delivered and released DOX within tumor cells, effectively suppressing growth of the tumor cells at a similar or even lower drug concentration than free DOX. Blank particles containing no DOX did not induce cytotoxicity to cells.