The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2018
Filed:
Oct. 03, 2016
Applicant:
Alere San Diego Inc., San Diego, CA (US);
Inventors:
Olaf Piepenburg, Essex, GB;
Niall A. Armes, Suffolk, GB;
Assignee:
Alere San Diego Inc., San Diego, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6816 (2018.01); C12Q 1/68 (2018.01); C07H 21/00 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6816 (2013.01); C07H 21/00 (2013.01); C12Q 2521/301 (2013.01); C12Q 2521/531 (2013.01); C12Q 2525/119 (2013.01);
Abstract
A new class of nucleic acid substrates for AP endonucleases and members of the glycosylase/lyase family of enzymes is described. Representatives of each family, the enzymes Nfo and fpg, respectively, cleave nucleic acid backbones at positions in which a base has been replaced by a linker to which a variety of label moieties may be attached. The use of these synthetic substrates embedded within oligonucleotides is of utility in a number of applications.