The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2018
Filed:
Mar. 11, 2016
Applicant:
Peter Maccallum Cancer Institute, East Melbourne, Victoria, AU;
Inventors:
Mark A. Dawson, Hawthorn East, AU;
Chun Yew Fong, Melbourne, AU;
Assignee:
Peter MacCallum Cancer Institute, East Melbourne, Victoria, AU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/09 (2010.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0694 (2013.01); G01N 33/5011 (2013.01); G01N 33/5044 (2013.01); C12N 2501/065 (2013.01);
Abstract
Bromodomain and extra terminal protein (BET) resistant leukemic cell lines and methods for producing such cell lines are described as are methods for using such cell lines in screening assays to identify therapeutic agents. The cell lines can be generated from haematopoietic stem and progenitor cells (HSPCs) that are clonally enriched by serially exposing c-kit positive cells to a BET inhibitor.