The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2018
Filed:
Sep. 10, 2013
Applicant:
Bio-technology General (Israel) Ltd., Rehovot, IL;
Inventors:
Assignee:
Bio-Technology General (Israel) Ltd., Rehovot, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/715 (2006.01); A61K 47/00 (2006.01); C07H 5/06 (2006.01); C08B 37/08 (2006.01); C08B 37/00 (2006.01); C12P 19/26 (2006.01); A61K 31/728 (2006.01);
U.S. Cl.
CPC ...
C08B 37/0072 (2013.01); A61K 31/728 (2013.01); C08B 37/0003 (2013.01); C12P 19/26 (2013.01);
Abstract
Manufactured hyaluronic acid products are used in numerous surgical applications including viscoelastic supplementation for the treatment of osteoarthritis, however, traditional sterilization techniques result in the breakdown of such high molecular o weight viscoelastic biopolymers and are thus unsuitable. Disclosed are processes for obtaining concentrated sterile solutions of high molecular weight biopolymers such as hyaluronic acid. The processes include filter sterilization with a dilute preparation of the biopolymer, and concentration of the dilute filter sterilized biopolymer by ultrafiltration to a desired concentration.