The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2018
Filed:
Mar. 14, 2014
Novo Nordisk A/s, Bagsvaerd, DK;
Berit O. Krogh, Roedovre, DK;
Mikael Kofod-Hansen, Koebenhavn N, DK;
Ida Hilden, Vanloese, DK;
Helle H. Petersen, Koebenhavn V, DK;
Lars C. Petersen, Hoersholm, DK;
Jens Breinholt, Dyssegaard, DK;
Novo Nordisk A/S, Bagsvaerd, DK;
Abstract
The application discloses a combination of two monospecific TFPI antibodies, wherein one antibody is capable of specifically binding TFPI (1-181) and the other antibody is capable of specifically binding TFPI (182-276), as well as bispecific anti-TFPI antibodies derived from two such monospecific antibodies. Both the combination of the two monospecific antibodies and the bispecific antibody strongly enhance thrombin generation by neutralising full length TFPIα, even where the concentration of TFPI is abnormally elevated.