The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2018
Filed:
Sep. 07, 2014
Applicant:
Rappaport Family Institute for Research IN the Medical Sciences, Haifa, IL;
Inventors:
Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); A61K 38/00 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4702 (2013.01); A61K 9/0019 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01);
Abstract
The present invention relates, according to some embodiments, to variants of Semaphorin 3C (Sema3C) having amino acid modifications at furin-like pro-protein convertase cleavage sites, rendering these sites resistant to cleavage. The invention further provides, according to certain embodiments, compositions comprising the Sema3C variants, and methods of using the compositions for suppressing the growth of tumors and/or inhibiting the development of tumor metastases.