The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2018
Filed:
Sep. 14, 2015
Agilent Technologies, Inc., Santa Clara, CA (US);
Douglas J. Dellinger, Boulder, CO (US);
Joel Myerson, Berkeley, CA (US);
Agnieszka Sierzchala, Boulder, CO (US);
Geraldine F. Dellinger, Boulder, CO (US);
Zoltan Timar, Boulder, CO (US);
Agilent Technologies, Inc., Santa Clara, CA (US);
Abstract
A method of deprotecting a solid support bound polynucleotide includes the step of contacting the polynucleotide with a composition comprising a diamine under conditions sufficient to deprotect the 2'-protected ribonucleotide residue. The solid support bound polynucleotide has at least one 2′-protected ribonucleotide residue, which has the following structure: wherein Bis a protected or unprotected heterocycle; Ris a protecting group selected from a hydrocarbyl, a substituted hydrocarbyl, an aryl, and a substituted aryl; X is O or S; and PG is a thionocarbamate protecting group.