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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9895451 B1

PDFFull Text
Date of Patent:
Feb. 20, 2018

Filed:

Nov. 18, 2014

Formulations for targeted release of agents to low ph tissue environments or cellular compartments and methods of use thereof

Applicant:

Yale University, New Haven, CT (US);

Inventors:

W. Mark Saltzman, New Haven, CT (US);

Junwei Zhang, New Haven, CT (US);

Jiangbing Zhou, Cheshire, CT (US);

Zhaozhong Jiang, New Haven, CT (US);

Assignee:

Yale University, New Haven, CT (US);

Attorney:

Pabst Patent Group LLP

Primary Examiner:

Janet L Epps-Smith

Int. Cl.
CPC ...
A61K 47/48 (2006.01); A61K 47/59 (2017.01); A61K 31/7088 (2006.01); A61K 9/51 (2006.01); C08G 63/685 (2006.01); A61K 47/34 (2017.01); A61K 9/107 (2006.01); C12N 15/87 (2006.01);
U.S. Cl.
CPC ...
A61K 47/593 (2017.08); A61K 9/5146 (2013.01); A61K 31/7088 (2013.01); C08G 63/685 (2013.01); A61K 9/1075 (2013.01); A61K 47/34 (2013.01); C12N 15/87 (2013.01);
Abstract

Polyamine-co-ester-co-ortho ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more efficient at drug delivery, or a combination thereof compared to a control or other transfection reagents.

Find Patent Forward Citations

Saltzman, W.. (2018). Formulations for targeted release of agents to low ph tissue environments or cellular compartments and methods of use thereof (U.S. Patent No. 9895451). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9895451

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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