The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2018
Filed:
Nov. 18, 2014
Applicant:
Yale University, New Haven, CT (US);
Inventors:
W. Mark Saltzman, New Haven, CT (US);
Junwei Zhang, New Haven, CT (US);
Jiangbing Zhou, Cheshire, CT (US);
Zhaozhong Jiang, New Haven, CT (US);
Assignee:
Yale University, New Haven, CT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/48 (2006.01); A61K 47/59 (2017.01); A61K 31/7088 (2006.01); A61K 9/51 (2006.01); C08G 63/685 (2006.01); A61K 47/34 (2017.01); A61K 9/107 (2006.01); C12N 15/87 (2006.01);
U.S. Cl.
CPC ...
A61K 47/593 (2017.08); A61K 9/5146 (2013.01); A61K 31/7088 (2013.01); C08G 63/685 (2013.01); A61K 9/1075 (2013.01); A61K 47/34 (2013.01); C12N 15/87 (2013.01);
Abstract
Polyamine-co-ester-co-ortho ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more efficient at drug delivery, or a combination thereof compared to a control or other transfection reagents.