The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2018
Filed:
Jun. 20, 2016
Applicant:
Cypralis Limited, Ongar, Essex, GB;
Inventors:
Assignee:
Cypralis Limited, Ongar, GB;
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/12 (2006.01); A61K 38/15 (2006.01); C07K 7/56 (2006.01); C07K 11/02 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/15 (2013.01); C07K 7/56 (2013.01); C07K 11/02 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention relates to novel cycloundecadepsipeptide compounds and their analogues which bind and inhibit cyclophilins, have reduced immunosuppressive activity and improved physicochemical properties including water solubility. The present invention further relates to pharmaceutical compositions containing said depsipeptide compounds and their analogues for use in the treatment or prevention of diseases and pathologies which may be ameliorated by the inhibition of cyclophilin activity.