The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2018
Filed:
Mar. 25, 2015
Applicant:
University of Kentucky Research Foundation, Lexington, KY (US);
Inventors:
Vitaliy M. Sviripa, Lexington, KY (US);
Wen Zhang, Lexington, KY (US);
Chunming Liu, Lexington, KY (US);
David Watt, Lexington, KY (US);
Assignee:
University of Kentucky Research Foundation, Lexington, KY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/136 (2006.01);
U.S. Cl.
CPC ...
A61K 31/136 (2013.01);
Abstract
Halogenated diarylacetylenes, e.g., diarylacetylenes having at least one halo substituent in one aryl ring and an amine in the opposing aryl ring, can inhibit the proliferation of LS174T colon cancer cells through the inhibition of c-myc and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)). Such compounds are useful as antineoplastic agents.