The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2018
Filed:
Dec. 10, 2014
Applicant:
Mie University, Tsu-shi, JP;
Inventors:
Assignee:
MIE UNIVERSITY, Tsu-Shi, JP;
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); A01K 67/02 (2006.01); C12N 15/873 (2010.01); C12N 15/90 (2006.01); C12N 9/64 (2006.01); C12N 15/85 (2006.01); C12N 15/09 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); A01K 67/027 (2013.01); C12N 9/6416 (2013.01); C12N 9/6491 (2013.01); C12N 15/8509 (2013.01); C12Y 304/24024 (2013.01); A01K 2217/052 (2013.01); A01K 2227/105 (2013.01); A01K 2267/035 (2013.01); A01K 2267/0368 (2013.01); C12N 15/09 (2013.01); C12N 2015/8527 (2013.01); C12N 2830/15 (2013.01);
Abstract
A transgenic non-human mammal has a genome that includes an early-immediate enhancer of human cytomegalovirus (CMV enhancer), a β-actin promoter and the entire gene region of human matrix metalloproteinase 2 (hMMP2) disposed downstream of the promoter. The hMMP2 is systemically expressed in the transgenic non-human mammal, which thus provides a suitable animal model for studying chronic obstructive pulmonary disease and related diseases and conditions.