The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2018
Filed:
Feb. 22, 2017
Applicants:
Jingyue Ju, Englewood Cliffs, NJ (US);
Zengmin LI, Flushing, NY (US);
Sergey Kalachikov, New York City, NY (US);
Carl Fuller, Berkeley Heights, NJ (US);
Inventors:
Jingyue Ju, Englewood Cliffs, NJ (US);
Zengmin Li, Flushing, NY (US);
Sergey Kalachikov, New York City, NY (US);
Carl Fuller, Berkeley Heights, NJ (US);
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, New York, NY (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); C07K 14/31 (2006.01); C12N 9/12 (2006.01); C12N 9/96 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6874 (2013.01); C07K 14/31 (2013.01); C12N 9/1252 (2013.01); C12N 9/96 (2013.01); C12Y 207/07007 (2013.01);
Abstract
The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as α-hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as DNA polymerase, and the use of such pore-forming protein conjugates in nanopore devices and methods.