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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9890185 B1

PDFFull Text
Date of Patent:
Feb. 13, 2018

Filed:

Dec. 19, 2014

Urea derivatives useful as kinase inhibitors

Applicants:

Respivert Limited, Buckinghamshire, GB;

Topivert Pharma Limited, London, GB;

Inventors:

Matthew Colin Thor Fyfe, London, GB;

Stephen Malcolm Thom, Nottingham, GB;

Thomas Matthew Baker, Nottingham, GB;

Gareth William Harbottle, Nottingham, GB;

Vedran Hasimbegovic, Nottingham, GB;

Aaron Rigby, Nottingham, GB;

Assignees:

Respivert Limited, Buckinghamshire, GB;

Topivert Pharma Limited, London, GB;

Attorney:

Knobbe, Martens, Olson & Bear, LLP

Primary Examiner:

Sarah Pihonak

Int. Cl.
CPC ...
C07F 9/6512 (2006.01); C07D 403/12 (2006.01); C07D 213/74 (2006.01); C07D 213/75 (2006.01); C07D 401/02 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 239/47 (2006.01); C07D 413/12 (2006.01); C07F 9/58 (2006.01); C07F 9/6558 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/496 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01); A61K 31/675 (2006.01);
U.S. Cl.
CPC ...
C07F 9/65127 (2013.01); A61K 31/44 (2013.01); A61K 31/444 (2013.01); A61K 31/4427 (2013.01); A61K 31/4439 (2013.01); A61K 31/496 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61K 31/675 (2013.01); C07D 213/74 (2013.01); C07D 213/75 (2013.01); C07D 239/47 (2013.01); C07D 401/02 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07F 9/582 (2013.01); C07F 9/588 (2013.01); C07F 9/65122 (2013.01); C07F 9/65583 (2013.01); C07F 9/65586 (2013.01);
Abstract

There are provided compounds of formula I, wherein R, R, Rto R, R, R, X, E and G have meanings given in the description, which compounds have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

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