The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2018
Filed:
Aug. 13, 2013
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Stephan Siegel, Berlin, DE;
Stefan Bäurle, Berlin, DE;
Arwed Cleve, Berlin, DE;
Bernard Haendler, Berlin, DE;
Amaury Ernesto Fernandez-Montalvan, Berlin, DE;
Ursula Mönning, Woltersdorf, DE;
Sabine Krause, Berlin, DE;
Pascale Lejeune, Berlin, DE;
Norbert Schmees, Berlin, DE;
Matthias Busemann, Berlin, DE;
Simon Holton, Berlin, DE;
Joachim Kuhnke, Potsdam, DE;
Bayer Pharma Aktiengesellshaft, Berlin, DE;
Abstract
What is described are BET protein-inhibitory, in particular BRD4-inhibitory 2,3-benzodiazepines of the general formula (I) in which R, R, R, R, R, R, R, A and X have the meanings given in the description, intermediates for preparing the compounds according to the invention, pharmaceutical compositions comprising the compounds according to the invention and their prophylactic and therapeutic use for hyperproliferative disorders, in particular for tumor disorders. Also described is the use of BET protein inhibitors for benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, for neurodegenerative disorders, for inflammatory disorders, for atherosclerotic disorders and for the control of male fertility.