The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2018
Filed:
Apr. 05, 2012
Pier Lucio Anelli, Milan, IT;
Maria Argese, Sedriano, IT;
Luciano Lattuada, Bussero, IT;
Sonia Gazzetto, Cascinette d'Ivrea, IT;
Laura Galimberti, Fara Gera d'Adda, IT;
Valeria Boi, Strambino, IT;
Livio Cavalieri, Milan, IT;
Fulvia Vella, Monza, IT;
Pier Lucio Anelli, Milan, IT;
Maria Argese, Sedriano, IT;
Luciano Lattuada, Bussero, IT;
Sonia Gazzetto, Cascinette d'Ivrea, IT;
Laura Galimberti, Fara Gera d'Adda, IT;
Valeria Boi, Strambino, IT;
Livio Cavalieri, Milan, IT;
Fulvia Vella, Monza, IT;
BRACCO IMAGING S.p.A., Milan, IT;
Abstract
The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chloro-sulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.