The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 13, 2018

Filed:

Oct. 22, 2014
Applicant:

Berkeley Lights, Inc., Emeryville, CA (US);

Inventors:

Kevin T. Chapman, Santa Monica, CA (US);

Daniele Malleo, El Cerrito, CA (US);

J. Tanner Nevill, El Cerrito, CA (US);

Steven W. Short, Pleasanton, CA (US);

Mark P. White, San Francisco, CA (US);

M Jimena Loureiro, Albany, CA (US);

Assignee:

Berkeley Lights, Inc., Emeryville, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); G01N 33/68 (2006.01); G01N 33/50 (2006.01); G01N 33/543 (2006.01); G01N 15/14 (2006.01); B03C 5/00 (2006.01); B03C 5/02 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502761 (2013.01); B03C 5/005 (2013.01); B03C 5/026 (2013.01); G01N 15/1484 (2013.01); G01N 33/505 (2013.01); G01N 33/5023 (2013.01); G01N 33/5047 (2013.01); G01N 33/5052 (2013.01); G01N 33/54313 (2013.01); G01N 33/6854 (2013.01); B01L 2200/0647 (2013.01); B01L 2200/0668 (2013.01); B01L 2300/0636 (2013.01); B01L 2300/087 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0864 (2013.01); B01L 2400/0454 (2013.01); B03C 2201/26 (2013.01);
Abstract

Biological activity in holding pens in a micro-fluidic device can be assayed by placing in the holding pens capture objects that bind a particular material of interest produced by the biological activity. The biological material of interest that binds to each capture object can then be assessed, either in the micro-fluidic device or after exporting the capture object from the micro-fluidic device. The assessment can be utilized to characterize the biological activity in each holding pen. The biological activity can be production of the biological material of interest. Thus, the biological activity can correspond to or arise from one or more biological cells. Biological cells within a holding pen can be clonal cell colonies. The biological activity of each clonal cell colony can be assayed while maintaining the clonal status of each colony.


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