The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2018
Filed:
Aug. 17, 2011
Applicants:
Rajiv Jalan, Chislehurst, GB;
Naina Shah, Croydon, GB;
Inventors:
Rajiv Jalan, Chislehurst, GB;
Naina Shah, Croydon, GB;
Assignee:
YAQRIT LIMITED, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 38/10 (2006.01); A61K 38/04 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 38/10 (2013.01); A61K 38/04 (2013.01); G01N 33/6893 (2013.01); G01N 2333/705 (2013.01); G01N 2500/00 (2013.01); G01N 2800/085 (2013.01); G01N 2800/28 (2013.01); G01N 2800/347 (2013.01); G01N 2800/52 (2013.01);
Abstract
The present invention derives from the finding that increased levels of Toll like receptor 4 (TLR4) is associated with liver failure and renal dysfunction and/or brain dysfunction and that by decreasing TLR4 levels in vivo, the kidney and brain consequences of liver disease that are precipitated by superimposed infection or inflammation may be reduced. Accordingly, the invention provides TLR4 antagonists for use in a method of treating an individual suffering from liver disease presenting with renal or brain dysfunction.