The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2018
Filed:
Oct. 14, 2015
Applicant:
Institute for Cancer Research, Philadelphia, PA (US);
Inventors:
Timothy J. Yen, Haverford, PA (US);
Vikram Bhattacharjee, Philadelphia, PA (US);
Assignee:
Institute For Cancer Research, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); A61K 31/55 (2006.01); A61K 31/7068 (2006.01); A61K 45/06 (2006.01); A61K 31/593 (2006.01);
U.S. Cl.
CPC ...
A61K 31/55 (2013.01); A61K 31/593 (2013.01); A61K 31/7068 (2013.01); A61K 45/06 (2013.01);
Abstract
Methods for treating tumors comprise contacting tumor cells expressing the vitamin D receptor with a vitamin D receptor ligand that inhibits homologous recombination in the tumor cells, and contacting the tumor cells with an amount of a Poly(ADP) Ribose Polymerase 1 (PARP-1) inhibitor. Inhibiting homologous recombination produces a synergistic therapeutic effect between the vitamin D receptor ligand and PARP-1 inhibitor, and may overcome PARP-1 resistance in killing tumor cells.