The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 06, 2018

Filed:

Feb. 21, 2013
Applicants:

Indiana University Research and Technology Corporation, Indianapolis, IN (US);

The Regents of the University of California, Oakland, CA (US);

Inventors:

Chris Ballas, Fishers, IN (US);

Masa Rao, Riverside, CA (US);

Yanyan Zhang, Houston, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/00 (2006.01); C12M 3/00 (2006.01); B01L 3/00 (2006.01); C12N 15/89 (2006.01); C12M 1/32 (2006.01); B01J 19/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/89 (2013.01); B01J 19/0046 (2013.01); C12M 23/12 (2013.01); B01J 2219/00452 (2013.01); B01J 2219/00502 (2013.01); B01J 2219/00587 (2013.01); B01J 2219/00743 (2013.01);
Abstract

Many applications in cell biology, genetic engineering, cell-based therapeutics, and drug discovery require precise and safe methods for introducing membrane-impermeable molecules into cells. This can be implemented satisfactorily by microinjection. However, disadvantages of traditional manual microinjection include high degree of operator skill, low throughput and labor-intensiveness. Many studies have focused on developing automated and high-throughput systems for microinjection to address these limitations. However, none have provided sufficient throughput for applications such as ex vivo cell therapy, where manipulation of many cells is helpful.


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