The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2018
Filed:
Jun. 11, 2015
Applicant:
Children's National Medical Center, Washington, DC (US);
Inventors:
Catherine M. Bollard, Bethesda, MD (US);
Conrad Russell Y. Cruz, Bethesda, MD (US);
Sharon Lam, Atlanta, GA (US);
Assignee:
CHILDREN'S NATIONAL MEDICAL CENTER, Washington, DC (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/00 (2006.01); A61K 45/06 (2006.01); C12N 5/0783 (2010.01); C12N 5/0784 (2010.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); A61K 45/06 (2013.01); C12N 5/0636 (2013.01); C12N 5/0638 (2013.01); C12N 5/0639 (2013.01); C12N 2501/22 (2013.01); C12N 2501/2301 (2013.01); C12N 2501/2304 (2013.01); C12N 2501/2306 (2013.01); C12N 2501/2307 (2013.01); C12N 2501/2312 (2013.01); C12N 2501/2315 (2013.01); C12N 2501/25 (2013.01); C12N 2501/998 (2013.01); C12N 2740/16034 (2013.01);
Abstract
Compositions for T cell-based immunotherapy of HIV, HIV-associated malignancies, HIV-associated viral infections, or other HIV-related complications. Modified T cells that are resistant to invasion or infection with HIV, such as T-cells modified to decrease or eliminate expression of mannosyl-oligosacharide glucosidase enzyme ('MOGS'). Methods for producing such compositions by expanding HIV-specific T cells from different sources to recognize multiple HIV antigens.