The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2018
Filed:
Mar. 11, 2013
Applicants:
Medimmune, Llc, Gaithersburg, MD (US);
Medimmune Limited, Cambridge, GB;
Inventors:
Ralph Minter, Cambirdge, GB;
Julie Douthwaite, Cambridge, GB;
Jacques Moisan, North Potomac, MD (US);
Michael Bowen, Gaithersburg, MD (US);
Steven Rust, Cambridge, GB;
Cyril Privezentzev, Sawston, GB;
Assignee:
MedImmune Limited, Cambridge, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70521 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01);
Abstract
Variants of cytotoxic T-lymphocyte antigen 4 (CTLA-4) with high affinity, potency and stability. Formulations of CTLA-4 variants at high concentration for subcutaneous or intravenous administration, e.g. at monthly or less frequent dosage intervals. Use of CTLA-4 variants for treating rheumatoid arthritis and other inflammatory disorders. Fusion of CTLA-4 with IgG Fc having improved stability and longer in vivo half-life.