The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2018
Filed:
Jan. 31, 2014
Institut National DE LA Recherche Agronomique, Paris, FR;
Centre National DE LA Recherche Scientifique, Paris, FR;
Massimiliano Beltramo, Monthodon, FR;
Vincent Aucagne, Fleury les Aubrais, FR;
Alain Caraty, Veigne, FR;
Agnes Delmas, Orleans, FR;
Mathieu Galibert, Orleans, FR;
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, Paris, FR;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris, FR;
Abstract
A KISS1R agonist peptide compound capable of inducing ovulation in a female mammal is provided. The compound is a pseudopeptide having the C-terminal sequence: -XaaΨ[Tz]Xaa2-Xaa3-Xaa4-NH(SEQ ID NO: 3), where Ψ[Tz] represents a 1,4-disubstituted 1,2,3-triazole group replacing the peptide bond between the Xaa1 residue and the Xaa2 residue, Xaa1 is Gly or Ala, Xaa2 is Leu or an aliphatic α-aminoacyl analog residue, Xaa3 is Arg, Arg(Me) or a positively charged α-aminoacyl analog residue, and Xaa4 is Tyr, Phe, Trp or an α-aminoacyl analog residue such as aryl alanine; or an analog of the pseudopeptide in which the amide peptide bond between Xaa2 and Xaa3 and/or between Xaa3 and Xaa4 is replaced with an isosteric bond, or a salt thereof.