The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2018
Filed:
Oct. 21, 2013
The Broad Institute, Inc., Cambridge, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Chris Dockendorff, Milwaukee, WI (US);
Andrew Germain, Somerville, MA (US);
Partha Pratim Nag, Somerville, MA (US);
Willmen Youngsaye, Cumberland, RI (US);
Sivaraman Dandapani, Malden, MA (US);
Benito Munoz, Newtonville, MA (US);
Patrick Faloon, Cambridge, MA (US);
Thomas Nieland, Somerville, MA (US);
Monty Krieger, Needham, MA (US);
Miao Yu, Quincy, MA (US);
Massachusetts Institute Of Technology, Cambridge, MA (US);
The Broad Institute, Inc., Cambridge, MA (US);
Abstract
This application describes compounds and methods that can inhibit Scavenger receptor class B, type I (SR-BI) activity, which compounds and methods can be used, for example, to mediate high-density lipoprotein (HDL) lipid uptake and treat hepatitis C viral infections. The compounds have the formula: wherein Rand Rare independently H, halogen, cyano, haloalkyl, haloalkyloxy or OMe; or Rand Rtogether are —O—CH— or —O—CF—O—; Ris H, halogen, cyano, haloalkyl or haloalkyloxy; Ris Calkyl, Ccycloalkyl, Ccycloalkylmethyl or Ccycloheteroalkyl, wherein the heteroatom is N or O; Ris H or CH; Ris Calkyl or Ccycloalkyl; and A, B, D and E are each, independently, CH, N, O or S, wherein at least one of A, B, D and E is N, and another of A, B, D and E is N, O or S.