The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2018
Filed:
Dec. 15, 2014
Peloton Therapeutics, Inc., Dallas, TX (US);
Darryl David Dixon, Somerset, NJ (US);
Jonas Grina, Coppell, TX (US);
John A. Josey, Dallas, TX (US);
James P. Rizzi, Irving, TX (US);
Stephen T. Schlachter, Dallas, TX (US);
Eli M. Wallace, Richardson, TX (US);
Bin Wang, Dallas, TX (US);
Paul Wehn, Dallas, TX (US);
Rui Xu, Dallas, TX (US);
Hanbiao Yang, Coppell, TX (US);
PELOTON THERAPEUTICS, INC., Dallas, TX (US);
Abstract
The present disclosure relates to cyclic sulfones and sulfoximines that are HIF-2a inhibitors and methods of making and using them for treating cancers. In another aspect, the present disclosure provides a pharmaceutical composition comprising a compound described herein and a pharmaceutically acceptable carrier or excipient. The compound may exist in an amorphous form, a crystalline form, or as a salt, solvate, or hydrate. In another aspect, the present disclosure provides a method of treating renal cell carcinoma by administrating a therapeutically effective amount of a compound described herein or a pharmaceutical composition thereof to a subject in need of such treatment.