The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2018
Filed:
Apr. 20, 2016
Applicant:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Inventors:
Zaneta Nikolovska-Coleska, Ann Arbor, MI (US);
Jeanne A. Stuckey, Fenton, MI (US);
Ahmed Mady, Ann Arbor, MI (US);
Lei Miao, Ann Arbor, MI (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/167 (2006.01); C07D 333/34 (2006.01); A61K 45/06 (2006.01); C07C 323/63 (2006.01); C07C 311/21 (2006.01); C07D 295/26 (2006.01); A61K 31/495 (2006.01); A61K 31/18 (2006.01); A61K 31/415 (2006.01); A61K 31/44 (2006.01); A61K 31/4409 (2006.01); A61K 31/443 (2006.01); A61K 31/4439 (2006.01); A61K 31/451 (2006.01); A61K 31/496 (2006.01); A61K 31/5355 (2006.01); C07C 311/29 (2006.01); C07C 229/64 (2006.01); C07C 233/81 (2006.01); C07C 235/56 (2006.01);
U.S. Cl.
CPC ...
C07D 333/34 (2013.01); A61K 31/167 (2013.01); A61K 31/18 (2013.01); A61K 31/415 (2013.01); A61K 31/44 (2013.01); A61K 31/443 (2013.01); A61K 31/4409 (2013.01); A61K 31/4439 (2013.01); A61K 31/451 (2013.01); A61K 31/495 (2013.01); A61K 31/496 (2013.01); A61K 31/5355 (2013.01); A61K 45/06 (2013.01); C07C 229/64 (2013.01); C07C 233/81 (2013.01); C07C 235/56 (2013.01); C07C 311/21 (2013.01); C07C 311/29 (2013.01); C07C 323/63 (2013.01); C07D 295/26 (2013.01);
Abstract
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.