The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2018
Filed:
Jun. 05, 2014
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem, IL;
Inventors:
Oren Tirosh, Ness Ziona, IL;
Ira Voloshin, Ashkelon, IL;
Shlomo Sasson, Jerusalem, IL;
Michal Obercyger, Ramat Gan, IL;
Zecharia Madar, Rehovot, IL;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/575 (2006.01); A61K 31/573 (2006.01); C07J 41/00 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
A61K 31/575 (2013.01); A61K 31/573 (2013.01); A61K 47/48023 (2013.01); A61K 47/48038 (2013.01); C07J 41/0005 (2013.01); C07J 41/0061 (2013.01); C07J 41/0088 (2013.01);
Abstract
Compositions and methods for treating diseases or disorders associated with the metabolic syndrome using conjugates of bile acids with basic amino acids or a decarboxylated amino acid such as agmatine are provided. Further provided are bile acid-basic amino acid conjugates including chenodeoxycholic acid with an amino acid selected from arginine, lysine, histidine, ornithine or a decarboxylated amino acid such as agmatine.