The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 06, 2018

Filed:

Dec. 10, 2015
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Phieng Siliphaivanh, Newton, MA (US);

Joey Methot, Westwood, MA (US);

Kathryn Ann Lipford, Boston, MA (US);

Danielle Molinari, Brookline, MA (US);

David L. Sloman, Brookline, MA (US);

David Witter, Norfolk, MA (US);

Hua Zhou, Acton, MA (US);

Christopher Boyce, Flemington, NJ (US);

Xianhai Huang, Warren, NJ (US);

Jongwon Lim, Lexington, MA (US);

David Guerin, Natick, MA (US);

Ganesh Babu Karunakaran, Tamil Nadu, IN;

Raman Kumar Bakshi, Edison, NJ (US);

Ziping Liu, Beijing, CN;

Jianmin Fu, Beijing, CN;

Zhilong Wan, Beijing, CN;

Wei Liu, Beijing, CN;

Assignee:

MERCK SHARP & DOHME CORP., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/437 (2006.01); A61K 31/4545 (2006.01); A61K 31/444 (2006.01); C07D 471/04 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/437 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); C07D 471/04 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are ERK2 inhibitors. The invention also provides a pharmaceutical composition comprising an effective amount of at least one compound of Formula (I) and a pharmaceutically acceptable carrier. The invention also provides a pharmaceutical composition comprising an effective amount of at least one compound of Formula (I) and an effective amount of at least one other pharmaceutically active ingredient (such as, for example, a chemotherapeutic agent), and a pharmaceutically acceptable carrier.


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