The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2018
Filed:
Apr. 03, 2014
Applicant:
Scpharmaceuticals Inc., Lexington, MA (US);
Inventors:
Scott A. Michaels, Lexington, MA (US);
Pieter Muntendam, Lexington, MA (US);
Glenn R. Larsen, Lexington, MA (US);
Assignee:
scPharmaceuticals Inc., Burlington, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/341 (2006.01); A61K 47/18 (2017.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 31/635 (2006.01); A61K 47/02 (2006.01);
U.S. Cl.
CPC ...
A61K 31/341 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 31/635 (2013.01); A61K 47/02 (2013.01); A61K 47/18 (2013.01);
Abstract
The present teachings relate to liquid pharmaceutical formulations of furosemide, where the pharmaceutical formulations include a molar excess of tris(hydroxymethyl)aminomethane to furosemide, have a pH in the range of 7 to 8.5, and a concentration of tris(hydroxymethyl)aminomethane greater than or equal to about 50 mM. The present teachings can improve the stability of liquid pharmaceutical formulations including furosemide and the suitability of such pharmaceutical formulations for subcutaneous administration or delivery.