The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2018
Filed:
Nov. 10, 2015
Applicant:
Thermo Fisher Scientific Inc., Lafayette, CO (US);
Inventors:
Anastasia Khvorova, Northborugh, MA (US);
Angela Reynolds, Conifer, CO (US);
Devin Leake, Denver, CO (US);
William Marshall, Boulder, CO (US);
Steven Read, Denver, CO (US);
Stephen Scaringe, Lafayette, CO (US);
Assignee:
Thermo Fisher Scientific Inc., Waltham, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 31/713 (2006.01); C12N 15/10 (2006.01); C12N 15/82 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 31/713 (2013.01); C12N 15/1048 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 15/1135 (2013.01); C12N 15/1136 (2013.01); C12N 15/1138 (2013.01); C12N 15/8218 (2013.01); C12Y 113/12007 (2013.01); C12Y 502/01008 (2013.01); C12N 2310/14 (2013.01); C12N 2310/31 (2013.01); C12N 2310/322 (2013.01); C12N 2320/10 (2013.01); C12N 2320/11 (2013.01); C12N 2320/13 (2013.01);
Abstract
Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for HAO1.