The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2018
Filed:
Dec. 20, 2012
Applicants:
Adaerata, Limited Partnership, Montreal, CA;
National Research Council Canada, Ottawa, CA;
Inventors:
Nabil G. Seidah, Verdun, CA;
Jianbing Zhang, Ottawa, CA;
Assignees:
ADAERATA, LIMITED PARTNERSHP, Montreal, CA;
NATIONAL RESEARCH COUNCIL OF CANADA, Ottawa, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/40 (2006.01); G01N 33/573 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); G01N 33/5735 (2013.01); C07K 2317/22 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/569 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); G01N 2333/96433 (2013.01);
Abstract
Antibodies (e.g., sdAbs) binding to PCSK9 are described. Nucleic acids encoding such Abs, host cells expressing such Abs and pharmaceutical composition comprising same are described. The use of these PCSK9-binding Abs for lowering low-density lipoprotein-cholesterol (LDL-C) levels and for the treatment of cardiovascular disorders, is also described.