The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2018
Filed:
Dec. 19, 2013
Applicant:
Aveo Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Heidi Okamura, Brookline, MA (US);
Sandra Abbott, Boston, MA (US);
Alisa C. Bell, Bedford, MA (US);
Kelly Kreuter, Arvada, CO (US);
Ronan O'Hagan, Arlington, MA (US);
Samantha Perino, Brighton, MA (US);
Hamid Tissire, Abington, MA (US);
William M. Winston, Jr., Marlborough, MA (US);
Jeno Gyuris, Lincoln, MA (US);
Assignee:
AVEO Pharmaceuticals, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); C07K 16/28 (2006.01); A61K 39/395 (2006.01); C12N 15/09 (2006.01); C12N 15/63 (2006.01); C12N 5/10 (2006.01); C12N 5/12 (2006.01); C12N 5/16 (2006.01); C07K 14/705 (2006.01); C07K 14/71 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); A61K 39/3955 (2013.01); C12N 15/09 (2013.01); C12N 15/63 (2013.01); A61K 2039/505 (2013.01); C07K 16/2863 (2013.01); C07K 2317/14 (2013.01); C07K 2317/24 (2013.01); C07K 2317/515 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C12N 5/10 (2013.01); C12N 5/12 (2013.01); C12N 5/16 (2013.01);
Abstract
Monoclonal antibodies that bind and inhibit activation of human Notch3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of Notch3.