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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9879043 B1

PDFFull Text
Date of Patent:
Jan. 30, 2018

Filed:

Jun. 06, 2014

Synthesis of non-natural cofactor analogs of s-adenosyl-l-methionine using methionine adenosyltransferase

Applicant:

University of Kentucky Research Foundation, Lexington, KY (US);

Inventors:

Jon Thorson, Lexington, KY (US);

Tyler Huber, Lexington, KY (US);

Jianjun Zhang, Lexington, KY (US);

Shanteri Singh, Lexington, KY (US);

Assignee:

University of Kentucky Research Foundation, Lexington, KY (US);

Attorneys:

Stites & Harbison PLLC

Sean P. Ritchie

Primary Examiner:

Lawrence E Crane

Int. Cl.
CPC ...
C07H 19/16 (2006.01); C12P 19/28 (2006.01); C12P 13/12 (2006.01); C12P 11/00 (2006.01); C12P 9/00 (2006.01); C12Q 1/48 (2006.01); C12P 19/40 (2006.01); C07D 405/14 (2006.01); C12P 17/18 (2006.01);
U.S. Cl.
CPC ...
C07H 19/16 (2013.01); C07D 405/14 (2013.01); C12P 17/188 (2013.01); C12P 19/40 (2013.01);
Abstract

The present disclosure relates to the synthesis of non-natural analogs of S-adenosyl-L-methionine (SAM) and/or of Se-adenosyl-L-methionine (SeAM) by reacting a methionine analog and adenosine triphosphate (ATP) in the presence of at least one methionine adenosyltransferase (MAT), and to use thereof with downstream SAM and/or SeAM utilizing enzymes. The non-natural analogs of SAM and/or SeAM have the general formula: where X is S or Se, and Ris an alkyl group.

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Quick Actions:

Thorson, Jon. (2018). Synthesis of non-natural cofactor analogs of s-adenosyl-l-methionine using methionine adenosyltransferase (U.S. Patent No. 9879043). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9879043

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