The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 30, 2018

Filed:

Apr. 23, 2017
Applicants:

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, CN;

Guangzhou Institute of Respiratory Disease, Guangzhou, CN;

Inventors:

Kefang Lai, Guangzhou, CN;

Xiaodong Liu, Guangzhou, CN;

Bonian Zhong, Guangzhou, CN;

Shan Zhong, Guangzhou, CN;

Chuqin Huang, Guangzhou, CN;

Assignee:

Other;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 36/00 (2006.01); C07D 493/04 (2006.01); A61K 36/264 (2006.01); A61K 31/36 (2006.01);
U.S. Cl.
CPC ...
C07D 493/04 (2013.01); A61K 31/36 (2013.01); A61K 36/264 (2013.01); A61K 2236/13 (2013.01); A61K 2236/33 (2013.01); A61K 2236/37 (2013.01); A61K 2236/39 (2013.01);
Abstract

The invention discloses a method for extracting high-purity asarinin and use thereof. The method comprises: putting crudepowder in an SFE-COdevice; under the conditions that an extraction kettle has a pressure of 30-40 Mpa and a temperature of 45-70° C., separating kettles I and II have a pressure of 5-10 Mpa, a temperature of 30-50° C. and the flow rate of COis 35-60 L/h, extracting for 60-240 min to obtain total volatile oil of; standing the total volatile oil offor 24-72 h at a low temperature, and carrying out suction filtration under reduced pressure to obtain crude asarinin; and re-crystallizing the crude asarinin in absolute ethanol twice to obtain pure asarinin. It is found for the first time that asarinin has a good cough-relieving activity and thus can be used in preparing medicines for treating various types of coughs.


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