The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 30, 2018

Filed:

Jul. 14, 2014
Applicant:

Kyoto University, Kyoto-shi, Kyoto, JP;

Inventors:

Masatoshi Hagiwara, Kyoto, JP;

Suguru Yoshida, Tokyo, JP;

Takamitsu Hosoya, Tokyo, JP;

Assignee:

KYOTO UNIVERSITY, Kyoto-Shi, Kyoto, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 473/40 (2006.01); C12Q 1/68 (2006.01); A61K 31/52 (2006.01);
U.S. Cl.
CPC ...
C07D 473/40 (2013.01); A61K 31/52 (2013.01); C12Q 1/6897 (2013.01); C12Q 2600/136 (2013.01);
Abstract

A compound and a pharmaceutical composition for disease associated with an abnormal splice variant, use of the compound and the pharmaceutical composition, or a screening method of the compound and the pharmaceutical composition are provided. One or more embodiments disclose a compound expressed by the following formula (I) or (I') or prodrugs or pharmaceutically acceptable salts thereof. Another one or more embodiments disclose a screening method using a DNA construct that is fused, arranged, or constructed so as to express different reporter genes for a wild-type splice variant and an abnormal splice variant that contributes to the development or progression of disease;


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