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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9878986 B1

PDFFull Text
Date of Patent:
Jan. 30, 2018

Filed:

Apr. 29, 2014

Compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same

Applicant:

Chong Kun Dang Pharmaceutical Corp., Seoul, KR;

Inventors:

Changsik Lee, Gyeonggi-do, KR;

Hyun-Mo Yang, Gyeonggi-do, KR;

Hojin Choi, Gyeonggi-do, KR;

Dohoon Kim, Gyeonggi-do, KR;

Soyoung Kim, Gyeonggi-do, KR;

Nina Ha, Gyeonggi-do, KR;

Hyojin Lim, Gyeonggi-do, KR;

Eunhee Ko, Gyeonggi-do, KR;

Seongae Yoon, Gyeonggi-do, KR;

Daekwon Bae, Gyeonggi-do, KR;

Assignee:

Chong Kun Dang Pharmaceutical Corp., Seoul, KR;

Attorneys:

Dentons US LLP

Stephanie Seidman

Primary Examiner:

Emily Bernhardt

Int. Cl.
CPC ...
C07D 231/56 (2006.01); C07D 209/14 (2006.01); C07D 213/40 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 413/12 (2006.01); C07D 239/26 (2006.01); C07D 215/12 (2006.01); C07D 213/75 (2006.01); C07D 295/215 (2006.01); C07D 239/42 (2006.01); C07D 213/74 (2006.01); C07D 309/08 (2006.01); C07D 309/10 (2006.01); C07D 317/58 (2006.01); C07D 405/12 (2006.01); C07D 407/12 (2006.01); C07D 417/12 (2006.01); C07D 265/30 (2006.01); C07D 319/18 (2006.01); C07D 207/08 (2006.01); C07D 207/10 (2006.01); C07D 209/08 (2006.01); C07D 211/26 (2006.01); C07D 211/46 (2006.01); C07D 211/52 (2006.01);
U.S. Cl.
CPC ...
C07D 231/56 (2013.01); C07D 207/08 (2013.01); C07D 207/10 (2013.01); C07D 209/08 (2013.01); C07D 209/14 (2013.01); C07D 211/26 (2013.01); C07D 211/46 (2013.01); C07D 211/52 (2013.01); C07D 213/40 (2013.01); C07D 213/74 (2013.01); C07D 213/75 (2013.01); C07D 215/12 (2013.01); C07D 239/26 (2013.01); C07D 239/42 (2013.01); C07D 265/30 (2013.01); C07D 295/215 (2013.01); C07D 309/08 (2013.01); C07D 309/10 (2013.01); C07D 317/58 (2013.01); C07D 319/18 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 407/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01);
Abstract

Provided are urea derivatives of Formula I: with histone deacetylase (HDAC) inhibitory activity, optical isomers thereof, pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising the same. The provided urea derivatives of Formula I are selective histone deacetylase (HDAC) inhibitors and are effective for the treatment of histone deacetylase-mediated diseases such as malignant tumors, inflammatory diseases, rheumatoid arthritis, and neurodegeneration.

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