The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 30, 2018

Filed:

Oct. 16, 2014
Applicant:

Evonik Degussa Gmbh, Essen, DE;

Inventor:

Renat Kadyrov, Frankfurt, DE;

Assignee:

Evonik Degussa GmbH, Essen, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 209/50 (2006.01); C07B 43/04 (2006.01); C07C 227/16 (2006.01); C07D 265/32 (2006.01); C07D 207/16 (2006.01); C07K 5/062 (2006.01); C07D 295/03 (2006.01); C07D 295/15 (2006.01); C07F 9/40 (2006.01); C07K 5/065 (2006.01); C07D 295/027 (2006.01);
U.S. Cl.
CPC ...
C07C 209/50 (2013.01); C07B 43/04 (2013.01); C07C 227/16 (2013.01); C07D 207/16 (2013.01); C07D 265/32 (2013.01); C07D 295/027 (2013.01); C07D 295/03 (2013.01); C07D 295/15 (2013.01); C07F 9/4006 (2013.01); C07F 9/4062 (2013.01); C07K 5/06026 (2013.01); C07K 5/06078 (2013.01);
Abstract

The present invention relates to a process for the preparation of amines, comprising the following steps: a. reaction of a (i) carboxylic acid amide of the general formula (I), or (ii) carboxylic acid diamide of the general formula (II), or (iii) di-, tri- or polypeptide, or (iv) peptide amide with carboxy-terminal amide function with an alkylating agent, b. addition of a hydrogenation catalyst to the reaction mixture in a molar ratio of from 1:10 to 1:100 000, based on carboxylic acid amide, carboxylic acid diamide, di-, tri- or polypeptide or peptide amide, c. reaction of the reaction mixture with hydrogen, where a hydrogen pressure of from 0.1 bar to 200 bar is established and where a temperature in a range of from 0° C. to 250° C. is established.


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