The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 30, 2018

Filed:

Apr. 07, 2016
Applicants:

Wei-heng Shih, Bryn Mawr, PA (US);

Wan Y. Shih, Bryn Mawr, PA (US);

Song Han, Philadelphia, PA (US);

Xiaomin Niu, Philadelphia, PA (US);

Shi Fang, Philadelphia, PA (US);

Inventors:

Wei-Heng Shih, Bryn Mawr, PA (US);

Wan Y. Shih, Bryn Mawr, PA (US);

Song Han, Philadelphia, PA (US);

Xiaomin Niu, Philadelphia, PA (US);

Shi Fang, Philadelphia, PA (US);

Assignee:

DREXEL UNIVERSITY, Philadelphia, PA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07F 7/00 (2006.01); A61K 49/18 (2006.01); A61K 49/00 (2006.01); C09K 11/02 (2006.01); C09K 11/66 (2006.01); B82Y 40/00 (2011.01); B82Y 15/00 (2011.01); B82Y 30/00 (2011.01);
U.S. Cl.
CPC ...
A61K 49/1836 (2013.01); A61K 49/0067 (2013.01); C09K 11/02 (2013.01); C09K 11/661 (2013.01); B82Y 15/00 (2013.01); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01); Y10S 977/774 (2013.01); Y10S 977/896 (2013.01); Y10S 977/927 (2013.01);
Abstract

An aqueous approach to synthesize capped SnS quantum dots (QDs) followed by optional capping molecule extension by attaching one or more extending molecules to the capping molecule via peptide bond formation at elevated temperature. The capped SnS QDs may have a capping molecule:Sn:S molar ratio of 16:3:1 to 16:12:1. A suspension of SnS QDs was heat-treated at 200° C. for 0.5-4 hrs. The obtained SnS QDs showed an NIR emission peak at 820-835 nm with an excitation wavelength at 690 nm. The as synthesized SnS QDs were found to have high positive zeta potential of ˜30 mV and thus were toxic to cells. By neutralizing the SnS QDs the cytotoxicity was reduced to an accepted level. The heat-treatment step can be obviated by adding a glycerol solution containing Sanions and capping molecule to a glycerol solution of Snions.


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