The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2018
Filed:
Jun. 24, 2014
Applicant:
Stealth Biotherapeutics Corp., Monaco, MC;
Inventors:
D. Travis Wilson, Newton, MA (US);
Robert A. Kloner, Toluca Lake, CA (US);
Assignee:
Stealth BioTherapeutics Corp, Monaco, MC;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/07 (2006.01); A61K 38/06 (2006.01); A61K 45/06 (2006.01); A61K 31/401 (2006.01); A61K 31/573 (2006.01);
U.S. Cl.
CPC ...
A61K 38/06 (2013.01); A61K 31/401 (2013.01); A61K 31/573 (2013.01); A61K 38/07 (2013.01); A61K 45/06 (2013.01);
Abstract
The disclosure provides methods and compositions for increasing SERCA2a expression levels in a mammalian subject in need thereof. The methods comprise administering to the subject a therapeutic amount of an aromatic-cationic peptide to subjects in need thereof. In some embodiments, the aromatic-cationic peptide is D-Arg-2'6′-Dmt-Lys-Phe-NH2, or a pharmaceutically acceptable salt thereof such as acetate or trifluoroacetate salt. In some embodiments, the subject has suffered a myocardial infarction.