The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2018
Filed:
Feb. 04, 2013
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Ru Chih Huang, Baltimore, MD (US);
David Mold, Baltimore, MD (US);
Christopher Ruland, Annapolis, MD (US);
Yu-Chuan Liang, Baltimore, MD (US);
Jong Ho Chun, Woodbine, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/7016 (2006.01); A61K 31/05 (2006.01); A61K 31/44 (2006.01); A61K 31/09 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7016 (2013.01); A61K 31/05 (2013.01); A61K 31/09 (2013.01); A61K 31/44 (2013.01); A61K 45/06 (2013.01);
Abstract
The present invention provides pharmaceutical compositions comprising derivatives of NDGA, including M4N (tetra-O-methyl nordihydroguaiaretic acid) and sorafenib and their use in the inhibition and treatment of neoplastic diseases, such as liver cancer, colon cancer, breast cancer, brain cancers and ovarian cancers, for example, in a subject. Compositions comprising derivatives of NDGA, including M4N, sorafenib and additional therapeutic agents are also provided.