logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9873894 B1

PDFFull Text
Date of Patent:
Jan. 23, 2018

Filed:

May. 15, 2014

Methods and compositions for treatment of a genetic condition

Applicant:

Sangamo Biosciences, Inc., Richmond, CA (US);

Inventors:

Anthony Conway, Richmond, CA (US);

Gregory J. Cost, Richmond, CA (US);

Russell Dekelver, Richmond, CA (US);

Edward J. Rebar, Richmond, CA (US);

Andreas Reik, Richmond, CA (US);

Fyodor Urnov, Richmond, CA (US);

Jianbin Wang, Richmond, CA (US);

H. Steve Zhang, Richmond, CA (US);

Assignee:

Sangamo Therapeutics, Inc., Richmond, CA (US);

Attorneys:

Pasternak Patent Law

Susan Abrahamson

Primary Examiner:

Antonio Galisteo Gonzalez

Int. Cl.
CPC ...
C12N 15/90 (2006.01); C12N 15/11 (2006.01); C07K 2/00 (2006.01); C12N 9/22 (2006.01);
U.S. Cl.
CPC ...
C12N 15/907 (2013.01); C07K 2/00 (2013.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 15/90 (2013.01); C12N 15/902 (2013.01); C07K 2319/81 (2013.01); C12N 2320/30 (2013.01); C12Y 301/21004 (2013.01);
Abstract

Methods and compositions comprising single guide RNAs targeted to an endogenous mammalian β globin gene (HBB), gamma globin gene (HBG1), B-cell lymphoma/leukemia 11A (BCL11A) gene, Kruppel-like factor 1 (KLF1) gene, CCR5 gene, CXCR4 gene, PPP1R12C (AAVS1) gene, hypoxanthine phosphoribosyltransferase (HPRT) gene, albumin gene, Factor VIII gene, Factor IX gene, Leucine-rich repeat kinase 2 (LRRK2) gene, Hungtingin (Htt) gene, rhodopsin (RHO) gene, Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, surfactant protein B gene (SFTPB), T-cell receptor alpha (TRAC) gene, T-cell receptor beta (TRBC) gene, programmed cell death 1 (PD1) gene, Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) gene, human leukocyte antigen (HLA) A gene, a LMP7 gene, a Transporter associated with Antigen Processing (TAP) gene, tapasin gene (TAPBP), a class II major histocompatibility complex transactivator (CIITA) gene, a dystrophin gene (DMD), a glucocorticoid receptor gene (GR), IL2RG gene or RFX5 for genetic alteration of cells are provided.

Find Patent Forward Citations

Loading…