The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 2018
Filed:
Jan. 23, 2015
Consiglio Nazionale Delle Ricerche, Rome, IT;
Daniele Catalucci, Segrate, IT;
Gianluigi Condorelli, Rome, IT;
CONSIGLIO NAZIONALE DELLE RICHERCHE, Rome, IT;
Abstract
The present invention concerns the field of ion channels, and in particular relates to peptides which are suitable for use in the treatment of conditions where the L-type calcium channel (LTCC) density and function is altered. LTCCs are located on the membrane of all excitable cells and control the small voltage gradient across the plasma membrane by allowing the flow of Caions down their electrochemical gradient. This Caflux is critical for numerous processes including cardiac action potential propagation, muscle contraction, Ca-dependent gene expression, synaptic efficacy, and cell survival by contributing to various signaling cascades. Reduction of the inward calcium current (I) conducted through the LTCCs is seen in several diseases and medications to improve or restores impaired intracellular Cahomeostasis are limited. The present invention reports mimetic peptides (MPs) that through a novel mechanism directly targets LTCCs and, by modulation of LTCC density and function, increases I. This invention supports a therapeutic role for MP to treat human diseases associated with altered cellular Cahomeostasis.