IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9873724 B1

PDFFull Text
Date of Patent:
Jan. 23, 2018

Filed:

Dec. 17, 2014

Pro-angiogenic peptides and peptide conjugates

Applicant:

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem, IL;

Inventors:

Shmuel Ben-Sasson, Jerusalem, IL;

Hadas Reuveni, Har Adar, IL;

Assignee:

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem, IL;

Attorney:

Vorys, Sater, Seymour and Pease LLP

Primary Examiner:

Marcela M Cordero Garcia

Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61P 11/00 (2006.01); C07K 14/705 (2006.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61L 27/54 (2006.01); A61L 31/16 (2006.01); A61K 9/00 (2006.01); A61K 47/34 (2017.01); C07K 5/09 (2006.01); C07K 5/10 (2006.01); C07K 5/11 (2006.01); C07K 7/06 (2006.01);
U.S. Cl.
CPC ...
C07K 14/705 (2013.01); A61K 9/008 (2013.01); A61K 9/0024 (2013.01); A61K 38/1816 (2013.01); A61K 38/1825 (2013.01); A61K 38/19 (2013.01); A61K 47/34 (2013.01); A61L 27/54 (2013.01); A61L 31/16 (2013.01); C07K 5/0817 (2013.01); C07K 5/10 (2013.01); C07K 5/1019 (2013.01); C07K 7/06 (2013.01); A61K 38/00 (2013.01); A61L 2300/25 (2013.01); A61L 2300/412 (2013.01); C07K 2319/033 (2013.01);
Abstract

Short bioactive sequences derived from the 2loop of the 7-transmembranal receptor of endothelial differentiation gene 3 (EDG3) useful in stimulation of angiogenesis, and peptide conjugates comprising a permeability enhancing moiety, are provided. Also provided are pharmaceutical compositions comprising the peptides and methods of use in conditions were insufficient blood-supply occurs, or which are associated with endothelia dysfunction such as peripheral vascular diseases, coronary artery diseases, cerebrovascular diseases, diabetes and delayed wound healing, pulmonary disease, eye diseases and pathological condition related to severe infection.

Find Patent Forward Citations

Loading…