The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 2018
Filed:
May. 08, 2014
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
David S. Eisenberg, Los Angeles, CA (US);
Alice Soragni, Los Angeles, CA (US);
Lin Jiang, Los Angeles, CA (US);
Assignee:
The Regents of the University of California, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61P 35/00 (2006.01); C07K 7/06 (2006.01); C07K 14/47 (2006.01); G06F 19/16 (2011.01); G06F 19/18 (2011.01);
U.S. Cl.
CPC ...
C07K 7/06 (2013.01); C07K 14/4711 (2013.01); C07K 14/4746 (2013.01); G06F 19/16 (2013.01); G06F 19/18 (2013.01); A61K 38/00 (2013.01); C07K 2319/10 (2013.01); C07K 2319/33 (2013.01); C07K 2319/70 (2013.01);
Abstract
This invention relates, e.g., to an inhibitory peptide or CPP inhibitor which specifically binds to p53 having an aberrant conformation (e.g., is aggregated or misfolded) and inhibits p53 amyloidogenic aggregation or restores proper folding of the misfolded protein. Methods of using the inhibitory peptide or CPP inhibitor (e.g. to treat subjects having tumors that comprise aggregated p53) are described.