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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9873718 B1

PDFFull Text
Date of Patent:
Jan. 23, 2018

Filed:

May. 08, 2014

Structure-based peptide inhibitors of p53 aggregation as a new approach to cancer therapeutics

Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

David S. Eisenberg, Los Angeles, CA (US);

Alice Soragni, Los Angeles, CA (US);

Lin Jiang, Los Angeles, CA (US);

Assignee:

The Regents of the University of California, Oakland, CA (US);

Attorney:

Gates & Cooper LLP

Primary Examiner:

Marcela M Cordero Garcia

Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61P 35/00 (2006.01); C07K 7/06 (2006.01); C07K 14/47 (2006.01); G06F 19/16 (2011.01); G06F 19/18 (2011.01);
U.S. Cl.
CPC ...
C07K 7/06 (2013.01); C07K 14/4711 (2013.01); C07K 14/4746 (2013.01); G06F 19/16 (2013.01); G06F 19/18 (2013.01); A61K 38/00 (2013.01); C07K 2319/10 (2013.01); C07K 2319/33 (2013.01); C07K 2319/70 (2013.01);
Abstract

This invention relates, e.g., to an inhibitory peptide or CPP inhibitor which specifically binds to p53 having an aberrant conformation (e.g., is aggregated or misfolded) and inhibits p53 amyloidogenic aggregation or restores proper folding of the misfolded protein. Methods of using the inhibitory peptide or CPP inhibitor (e.g. to treat subjects having tumors that comprise aggregated p53) are described.

Find Patent Forward Citations

Eisenberg, David. (2018). Structure-based peptide inhibitors of p53 aggregation as a new approach to cancer therapeutics (U.S. Patent No. 9873718). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9873718

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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