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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9873716 B1

PDFFull Text
Date of Patent:
Jan. 23, 2018

Filed:

Jun. 16, 2015

Macrocyclic inhibitors of flaviviridae viruses

Applicants:

Gilead Sciences, Inc., Foster City, CA (US);

Cypralis Limited, Babraham, Cambridge, GB;

Inventors:

Caroline Aciro, Bottisham, GB;

David Kenneth Dean, Ware, GB;

Neil Andrew Dunbar, Chelmsford, GB;

Adrian John Highton, Chelmsford, GB;

Petr Jansa, San Mateo, CA (US);

Kapil Kumar Karki, Foster City, CA (US);

Andrew J. Keats, Essex, GB;

Linos Lazarides, London, GB;

Richard L. Mackman, Millbrae, CA (US);

Simon N. Pettit, Essex, GB;

Karine G. Poullennec, Essex, GB;

Adam James Schrier, Redwood City, CA (US);

Dustin Siegel, San Carlos, CA (US);

Victoria Alexandra Steadman, Essex, GB;

Assignees:

Gilead Sciences, Inc., Foster City, CA (US);

Cypralis Limited, Cambridge, GB;

Attorney:

Sheppard Mullin Richter & Hampton LLP

Primary Examiner:

Kaipeen Yang

Int. Cl.
CPC ...
A61K 38/21 (2006.01); C07K 5/062 (2006.01); C07D 487/08 (2006.01); C07D 498/08 (2006.01); C07D 498/18 (2006.01); A61K 38/12 (2006.01); A61K 39/29 (2006.01); A61K 45/06 (2006.01); C07K 5/02 (2006.01); C07D 471/18 (2006.01); C07D 498/22 (2006.01); A61K 38/55 (2006.01); A61K 31/403 (2006.01); A61K 31/497 (2006.01); A61K 31/504 (2006.01); A61K 31/7056 (2006.01); A61K 31/7072 (2006.01); C07K 5/078 (2006.01); C07K 5/065 (2006.01); A61K 38/15 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 5/06034 (2013.01); A61K 31/403 (2013.01); A61K 31/497 (2013.01); A61K 31/504 (2013.01); A61K 31/7056 (2013.01); A61K 31/7072 (2013.01); A61K 38/12 (2013.01); A61K 38/21 (2013.01); A61K 38/55 (2013.01); A61K 39/29 (2013.01); A61K 45/06 (2013.01); C07D 471/18 (2013.01); C07D 487/08 (2013.01); C07D 498/08 (2013.01); C07D 498/18 (2013.01); C07D 498/22 (2013.01); C07K 5/02 (2013.01); C07K 5/0606 (2013.01); C07K 5/06052 (2013.01); C07K 5/06078 (2013.01); C07K 5/06139 (2013.01); A61K 38/00 (2013.01); A61K 38/15 (2013.01);
Abstract

Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.

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