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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9873707 B1

PDFFull Text
Date of Patent:
Jan. 23, 2018

Filed:

Oct. 14, 2014

Methods and intermediates for preparing macrolactams

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Feng Xu, Staten Island, NY (US);

Richard Desmond, Lebanon, NJ (US);

Guy R. Humphrey, Hillsborough, NJ (US);

Hongming Li, Westfield, NJ (US);

Ji Qi, Beijing, CN;

Rebecca T. Ruck, Jersey City, NJ (US);

Zhiguo Jake Song, Edison, NJ (US);

Tao Wang, Berkeley Heights, NJ (US);

Yong-Li Zhong, Edison, NJ (US);

Jeonghan Park, Whippany, NJ (US);

Laura Marie Artino, Oakhurst, NJ (US);

Richard John Varsolona, Scotch Plains, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Julie M. Lake

John C. Todaro

Primary Examiner:

Jeffrey E Russel

Int. Cl.
CPC ...
C07C 69/14 (2006.01); C07K 5/083 (2006.01); C07D 498/16 (2006.01); C07C 69/63 (2006.01); C07D 403/12 (2006.01); C07C 269/04 (2006.01); C07C 271/34 (2006.01); C07C 231/12 (2006.01); C07K 5/062 (2006.01); C07C 27/20 (2006.01); C07C 29/36 (2006.01); C07C 29/58 (2006.01); C07C 45/00 (2006.01); C07C 45/63 (2006.01); C07K 5/12 (2006.01);
U.S. Cl.
CPC ...
C07D 498/16 (2013.01); C07C 27/20 (2013.01); C07C 29/36 (2013.01); C07C 29/58 (2013.01); C07C 45/00 (2013.01); C07C 45/63 (2013.01); C07C 69/14 (2013.01); C07C 69/63 (2013.01); C07C 231/12 (2013.01); C07C 269/04 (2013.01); C07C 271/34 (2013.01); C07D 403/12 (2013.01); C07K 5/06034 (2013.01); C07K 5/0808 (2013.01); C07K 5/126 (2013.01); C07C 2601/02 (2017.05);
Abstract

The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.

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