The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 23, 2018

Filed:

Jul. 11, 2014
Applicants:

Nippon Chemiphar Co., Ltd., Tokyo, JP;

Kyushu University, Fukuoka, JP;

Inventors:

Shogo Sakuma, Saitama, JP;

Kunio Kobayashi, Saitama, JP;

Masatoshi Ushioda, Tokyo, JP;

Daisuke Saito, Tokyo, JP;

Toshiyasu Imai, Tokyo, JP;

Kazuhide Inoue, Tokyo, JP;

Assignees:

NIPPON CHEMIPHAR CO., LTD, Tokyo, JP;

KYUSHU UNIVERSITY, Fukuoka, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 243/12 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 403/10 (2006.01); C07D 401/04 (2006.01); C07D 403/08 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01);
U.S. Cl.
CPC ...
C07D 403/10 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/08 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01);
Abstract

The present invention relates to a compound represented by the following general formula (II), wherein, in the formula, Rto Rrepresent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, and the like, Xrepresents C or N, Yrepresents N or C(═O), provided that when Xis C, Yrepresents N, and when Xis N, Yrepresents C(═O), the double line consisting of the solid line and the broken line represents a single bond or double bond, Arepresents benzene ring, pyridine ring, and the like, Drepresents tetrazole ring, imidazole ring, and the like, Erepresents —(CRR)-T-, and Grepresents benzene ring, pyridine ring, and the like, which has a P2X4 receptor antagonistic activity.


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