The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 2018
Filed:
Oct. 23, 2015
Applicants:
Salk Institute for Biological Studies, La Jolla, CA (US);
The University of Sydney, Darlington, NSW, AU;
Inventors:
Ning Ding, Riverside, CA (US);
Michael Downes, San Diego, CA (US);
Christopher Liddle, Chertswood, AU;
Ronald M. Evans, La Jolla, CA (US);
Assignees:
Salk Institute for Biological Studies, San Diego, CA (US);
The University of Sydney, Sydney, AU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/592 (2006.01); A61K 31/07 (2006.01); A61K 31/59 (2006.01); A61K 31/593 (2006.01); A61K 45/06 (2006.01); A61K 31/7068 (2006.01); G01N 33/50 (2006.01); G01N 33/82 (2006.01); A61K 9/16 (2006.01); A61K 47/54 (2017.01); A61K 47/62 (2017.01); A61K 47/69 (2017.01);
U.S. Cl.
CPC ...
A61K 31/592 (2013.01); A61K 9/167 (2013.01); A61K 31/07 (2013.01); A61K 31/59 (2013.01); A61K 31/593 (2013.01); A61K 31/7068 (2013.01); A61K 45/06 (2013.01); A61K 47/542 (2017.08); A61K 47/62 (2017.08); A61K 47/6929 (2017.08); A61K 47/6931 (2017.08); G01N 33/5058 (2013.01); G01N 33/82 (2013.01); G01N 2500/10 (2013.01); G01N 2800/085 (2013.01);
Abstract
The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.