The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 2018
Filed:
Dec. 12, 2013
Applicant:
The Charlotte-mecklenburg Hospital Authority, Charlotte, NC (US);
Inventors:
Assignee:
THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY, Charlotte, NC (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/381 (2006.01); A61K 45/06 (2006.01); A61K 31/4025 (2006.01); A61K 31/7105 (2006.01); A61K 47/54 (2017.01); A61K 47/64 (2017.01); A61K 47/66 (2017.01);
U.S. Cl.
CPC ...
A61K 31/381 (2013.01); A61K 31/4025 (2013.01); A61K 31/7105 (2013.01); A61K 45/06 (2013.01); A61K 47/549 (2017.08); A61K 47/643 (2017.08); A61K 47/66 (2017.08);
Abstract
The present invention provides methods for treating or preventing portal hypertension comprising administering to a patient in need of such treatment or prevention at least one Rev-erb modulating agent (REMA) in an amount effective to treat or prevent said portal hypertension. The REMA can be SR6452 or a related compound, such as SR9009 or SR9011. The amount of the REMA administered can comprises a quantity sufficient to modulate Rev-erbα expression, activity, and/or subcellular location and/or to inhibit or reverse hepatic stellate cell (HSC) activation and contractility.